Elane Bennis

Neutrophil elastase (ec 3.4.21.37, leukocyte elastase, elane, ela2, elastase 2, neutrophil, elaszym, serine elastase, subtype human leukocyte elastase (hle)) is a serine proteinase in the same family. The elane gene provides instructions for making a protein called neutrophil elastase. Nov 13, 2025elane (elastase, neutrophil expressed) is a protein coding gene.

Diseases associated with elane include cyclic neutropenia and neutropenia, severe congenital, 1, autosomal dominant. Jan 23, 2014in one, elane mutations lead to mislocalization of ne. In the other, elane mutations disturb protein folding, inducing an unfolded protein response in the endoplasmic reticulum (er).

Elane genetic analysis - ela2-related neutropenia includes congential and cyclic neutropenia. Explore the elane gene, its role in neutrophil elastase production, and the implications of mutations for various diseases. Oct 1, 2021the formation of the h1-dd elane complex may mediate reactive oxygen species at mitochondria and play a vital role in the anticancer selectivity of elane

Apr 22, 2021elane mutation was first mentioned in the horwitz report on neutrophil elastase as a cause for cyclic neutropenia, and the next year, the same team identified elane mutations in. Elane (ela2, hle, hne, ne, pmn-e) protein expression summary. Nov 27, 2024paediatric autoimmune diseases with elane mutations associated with neutropenia.